Distribution of ENCODE functional regions genome-wide and in the top 1% of iHS hits.

<p>Categories are the 7 identified ENCODE functional regions inferred from the combined ChromHMM and Segway results plus the “none” category indicating loci without functional annotation. All categories except for weak enhancers (WE) show significant differences between the two datasets with a <i>P</i> <0.0063 by a χ² test. CTCF: CTCF enriched element; WE:Weak Enhancer; T:Transcribed Region; E: Enhancer; PF:Promoter Flank; R: Repressed/Low Activity; TSS: promoter region including transcription start site.