Pocket similarity score predicts that polymerization increases PC190723 binding affinity.

<p>(A) Geometry of the FtsZ dimer structure. FtsZ subunits were initialized from the GDP-bound <i>S</i>. <i>aureus</i> wild-type structure (PDB ID: 3VO8). (B) PocketFEATURE scores of the dynamic FtsZ dimer structure show that the PC190723-binding pocket close to the dimer interface has significantly more pocket similarity to the <i>Sa</i>FtsZ-PC190723 co-crystal than the more exposed pocket on the end of the dimer. Thick lines are smoothed versions of the raw data (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004117#sec009" target="_blank">Methods</a>). WT, wildtype.