Micro CT analysis of Snx10 KD mice.

<p>(A, top) Surface images of the femur demonstrate a deficiency of mineralized cortical bone. Longitudinal mid-plane images of the femur (A, bottom) show a marrow cavity filled with unresorbed bone in Snx10 KD mice. Other examined bones: head, (B) and mandible (C) also were deficient in cortical bone, producing a “moth-eaten” appearance. Cross sectional micro CT images of femur (D, E, F and G) reveal the presence of an inner ring of cortex-like (i.e., denser) bone in Snx10 KD bones (E and G).