A table-top prototype has been constructed that uses the enzyme malate dehydrogenase to recognize input signal patterns. The device is controlled by the enzyme in response to injection of Mg2+ used as a signaling substance. Output is monitored spectroscopically. If Mg2+ is injected along either of two signal lines (i.e., if the input signal pattern is 10 or 01) the device emits an output of 1. Injection along neither or both lines results in an output of 0. The enzyme in effect is used as a transform that converts the linearly inseparable exclusive-or problem into a linearly separable problem
A notable need exists for noninvasive tools to increase our mechanistic understanding of disease pro...
Current computers are limited by the von Neumann bottleneck, which constrains the throughput between...
We have developed a new amplification system for proteinases that is sensitive, simple, and inexpens...
The conformational dynamics of enzymes is a computational resource that fuses milieu signals in a no...
Today's computers are built up from a minimal set of standard pattern recognition operations. Logic ...
Abstract—Today’s computers are built up from a minimal set of standard pattern recognition opera-tio...
ABSTRACT: Here, we demonstrate a strategy to convert the graded Michaelis−Menten response typical of...
Here, we demonstrate a strategy to convert the graded Michaelis−Menten response typical of unregula...
This dissertation will explore two different methods of generating enzymatically-amplified signals i...
Based on enzymatic reactions-triggered changes of pH values and biocomputing, a novel and multistage...
Malate dehydrogenase (MDH) is an enzyme that has a key role in biological processes, like the Krebs ...
An important goal in modern biology is to understand how molecular processes commonly studied at the...
In protein engineering, investigations of catalytic cycle facilitate rational design of enzymes. In ...
International audienceThe metabolic engineering of pathways has been used extensively to produce mol...
*S Supporting Information ABSTRACT: In this article, we describe a nonlinear threshold chemistry bas...
A notable need exists for noninvasive tools to increase our mechanistic understanding of disease pro...
Current computers are limited by the von Neumann bottleneck, which constrains the throughput between...
We have developed a new amplification system for proteinases that is sensitive, simple, and inexpens...
The conformational dynamics of enzymes is a computational resource that fuses milieu signals in a no...
Today's computers are built up from a minimal set of standard pattern recognition operations. Logic ...
Abstract—Today’s computers are built up from a minimal set of standard pattern recognition opera-tio...
ABSTRACT: Here, we demonstrate a strategy to convert the graded Michaelis−Menten response typical of...
Here, we demonstrate a strategy to convert the graded Michaelis−Menten response typical of unregula...
This dissertation will explore two different methods of generating enzymatically-amplified signals i...
Based on enzymatic reactions-triggered changes of pH values and biocomputing, a novel and multistage...
Malate dehydrogenase (MDH) is an enzyme that has a key role in biological processes, like the Krebs ...
An important goal in modern biology is to understand how molecular processes commonly studied at the...
In protein engineering, investigations of catalytic cycle facilitate rational design of enzymes. In ...
International audienceThe metabolic engineering of pathways has been used extensively to produce mol...
*S Supporting Information ABSTRACT: In this article, we describe a nonlinear threshold chemistry bas...
A notable need exists for noninvasive tools to increase our mechanistic understanding of disease pro...
Current computers are limited by the von Neumann bottleneck, which constrains the throughput between...
We have developed a new amplification system for proteinases that is sensitive, simple, and inexpens...