Decreased MRPS34 affects the stability of the 12S rRNA and specific mitochondrial mRNAs.

<p>(A) The abundance of mature mitochondrial transcripts in mitochondria isolated from young <i>Mrps34</i>^<i>wt/wt</i> and <i>Mrps34</i>^{<i>mut/mut</i>} livers and hearts was analyzed by northern blotting. (B) The abundance of mature mitochondrial transcripts in aged liver and heart was analyzed by northern blotting. 18S rRNA was used as a loading control. The data are representative of results obtained from at least 8 mice from each strain. Data are means ± SEM of three separate experiments; *, <i>p</i> < 0.05 compared with control treatments by a 2-tailed paired Student’s <i>t</i> test.