Effect of <i>A</i>. <i>phagocytophilum</i> infection on adult female midguts and salivary glands.

<p>The number of highly differentially expressed genes and represented proteins was higher in tick midguts than in salivary glands, suggesting a higher impact of bacterial infection in midgut cells probably associated with <i>A</i>. <i>phagocytophilum</i> developmental cycle. In tick midguts, <i>A</i>. <i>phagocytophilum</i> inhibited cell apoptosis to facilitate and establish infection through up-regulation of the JAK/STAT pathway genes. In tick salivary glands, down-regulation of Porin resulted in the inhibition of the Cytochrome c release that inhibited the mitochondrially-induced intrinsic apoptosis pathway to facilitate bacterial infection. This effect was contrasted in part by the induction of the extrinsic apoptosis pathway through the inhibition of FAS proteins.