Annotation of Perforin/Granzyme and other apoptosis pathway genes and expression in response to <i>A</i>. <i>phagocytophilum</i> infection.

<p>All apoptosis pathways described in other organisms were identified in <i>I</i>. <i>scapularis</i>, except for the absence of the Perforin ortholog in the Perforin/Granzyme pathway. (A) Perforin/Granzyme pathway. (B) Other apoptosis-related genes. For annotation, gene identifiers were obtained from VectorBase (<a href="http://www.vectorbase.org" target="_blank">www.vectorbase.org</a>) and compared to the corresponding pathways in <i>Drosophila melanogaster</i>, <i>Anopheles gambiae</i>, <i>Aedes aegypti</i> and <i>Homo sapiens</i>. Differential expression (P<0.05) is shown for tick nymphs (N) and adult midguts (G) and salivary glands (SG). (C) Schematic representation of predicted apoptosis pathways in <i>I</i>. <i>scapularis</i>.