Relative changes (%) in both creatinine and cystatin C based different spectrum of baseline estimates.

<p>Total of 37 severe patients included in this graph (non-survivors = 17 patients). In all the survivors, baseline was assumed as lowest concentrations during the hospital stay or at follow up. Baseline serum creatinine level in non-survivors was estimated by solving MDRD formula for GFR of 75 ml/min [black bolded line in the graph- serum creatinine (MDRD75)] or 0.9 mg/dl (75% of survivors had baseline levels below 0.9 mg/dl) (black dotted line- serum creatinine (75th centile). Similarly, baseline serum cystatin C in non-survivors was assumed as lowest values obtained (orange line) or estimated by solving cystatin C based CKD-EPI formulas (pink line) 21 for GFR of 75 ml/min [133 × (Cystatin C /0.8)−1.328 × 0.996Age (× 0.932 if female)].