<p>Respiratory system elastance (Ers) (A and B) and resistance (Rrs) (C and D) was recorded in wild-type and mutant mice. We performed a dose response curve to methacholine and values were obtained 30 seconds after each infusion (panels B and D). We also analyzed the percentage of maximal responses related to baseline (A and C). Data are expressed as mean and standard error of the 6–8 animals per group. *p<0.05 compared to wild-type.</p
<p>A) Male Balb/c mice were sensitized and challenged as shown. AHRs were determined on Day 33. B) I...
The relative contributions of large and small airways to hyperresponsiveness in asthma have yet to b...
Abstract Background Considerable variation exists in the protocols used to induce hyperresponsivenes...
<p>Airway resistance curves to methacholine for (A) WT and (B) PHIL mice; (C) Maximal airway resista...
<p>The airway resistance (R), after increasing concentrations of methacholine (0–10 mg/ml), was meas...
<p>(A) Log<sub>2</sub>(Penh) response curve to increasing doses of methacholine in A/J, C57BL/6J, Bc...
<p>A) Bronchial hyperresponsiveness (BHR) to methacholine was determined at Day 75 in unrestrained c...
<p>. (A) Enhanced pause (Penh) in response to 15 mg/ml of methacholine was measured in A/J, C57BL/6J...
<p>Mice with OVA-induced EAB (EAB-Mice), with/without treatment with sPLA<sub>2</sub> inhibitor (EAB...
Responsiveness is expressed as the peak Ers or Rrs after administration of 160 μg/kg methacholine mi...
Many chronic human lung diseases have their origin in early childhood, yet most murine models used t...
<p>With different doses of MCH: (A) R-area of Re. (B) R-area of Ri; (C) the peak value of Cdyn. Anim...
<p>Twenty-four hours after the last challenge, the respiratory pattern was assessed in control and m...
A method for the noninvasive measurement of airway responsiveness was validated in allergic BALB/c m...
<p>After last OVA challenge, mice were exposed to a series of incremental dosages of methacholine (6...
<p>A) Male Balb/c mice were sensitized and challenged as shown. AHRs were determined on Day 33. B) I...
The relative contributions of large and small airways to hyperresponsiveness in asthma have yet to b...
Abstract Background Considerable variation exists in the protocols used to induce hyperresponsivenes...
<p>Airway resistance curves to methacholine for (A) WT and (B) PHIL mice; (C) Maximal airway resista...
<p>The airway resistance (R), after increasing concentrations of methacholine (0–10 mg/ml), was meas...
<p>(A) Log<sub>2</sub>(Penh) response curve to increasing doses of methacholine in A/J, C57BL/6J, Bc...
<p>A) Bronchial hyperresponsiveness (BHR) to methacholine was determined at Day 75 in unrestrained c...
<p>. (A) Enhanced pause (Penh) in response to 15 mg/ml of methacholine was measured in A/J, C57BL/6J...
<p>Mice with OVA-induced EAB (EAB-Mice), with/without treatment with sPLA<sub>2</sub> inhibitor (EAB...
Responsiveness is expressed as the peak Ers or Rrs after administration of 160 μg/kg methacholine mi...
Many chronic human lung diseases have their origin in early childhood, yet most murine models used t...
<p>With different doses of MCH: (A) R-area of Re. (B) R-area of Ri; (C) the peak value of Cdyn. Anim...
<p>Twenty-four hours after the last challenge, the respiratory pattern was assessed in control and m...
A method for the noninvasive measurement of airway responsiveness was validated in allergic BALB/c m...
<p>After last OVA challenge, mice were exposed to a series of incremental dosages of methacholine (6...
<p>A) Male Balb/c mice were sensitized and challenged as shown. AHRs were determined on Day 33. B) I...
The relative contributions of large and small airways to hyperresponsiveness in asthma have yet to b...
Abstract Background Considerable variation exists in the protocols used to induce hyperresponsivenes...