Matrix-metalloproteinase (MMP) gelatinase activity and reactive oxygen species (ROS) production in the heart tissues of TFAM mice and Twinkle (TW) mice at 8weeks after creating arteriovenous fistula.

<p>(A) Representative images and quantification of MMP gelatinase activities in LV from TFAM or TW mice at 8 weeks after creating AVF (n = 6), **<i>P</i> < 0.01 vs. WT+Sham, ^†<i>P</i> < 0.01 vs. WT+VO, ^††<i>P</i> < 0.01 vs. WT+VO, analyzed by one-way ANOVA followed by post hoc Tukey’s test. (B) Representative images and quantification of Dihydroethidium staining (DHE) staining of LV from TFAM or TW mice (n = 6), **<i>P</i> < 0.01 vs. WT+Sham, ^†<i>P</i> < 0.01 vs. WT+VO, ^††<i>P</i> < 0.01 vs. WT+VO, analyzed by one-way ANOVA followed by post hoc Tukey’s test. Scale bar, 100μm. All data are mean±SEM.