Retinal responses in <i>rd/rd cl</i> mice.

<p>A: Trial bin count examples (5 second bins of time) of three cells responding to a 20s 71% contrast step (background log 12.8 to step log 13.56 melanopsin photons/cm2/s) in a <i>rd/rd cl</i> retina. Note the variety in the latency of response offset in examples 1 and 2, and the poor response reproducibility that is typical of <i>rd/rd cl</i> mice in example 3. Colour bar to the right of the plot (FR Hz) denotes the firing rate of cells in this and subsequent Trial bin count figures. B: Averaged plots for firing rate over time of melanopsin-step responsive cells (mean±SEM) to a 20s step (Bi n = 15) and a 60s step (Bii n = 17). Both step durations elicit a significant change in firing to the baseline rate (**** P<0.0001). C: A plot of mean onset and offset latencies for each individual responsive cell over multiple stimulus repeats reveals the extremely sluggish nature of light responses in <i>rd/rd cl</i> mice.