SDG decreases iron-induced inflammatory cytokine gene expression in H9c2 cells.

<p>Gene expression of inflammatory cytokines in control, 50 μM iron-treated, 500 μM secoisolariciresinol diglucoside (SDG), and SDG pre-treatment + iron-treated H9c2 cells. mRNA levels of tumor necrosis factor (TNF)-α (A), interleukin (IL)-10 (B), and interferon (IFN)γ (C) were determined via quantitative real-time PCR and normalized to β2-microglobulin, with normal expression standardized to the control. (*** = p < 0.001 versus control; * = p < 0.05 versus control, <i>n</i> = 3).