Tandem core technology.
- Hadrien Peyret (715792)
- Annick Gehin (715793)
- Eva C. Thuenemann (715794)
- Donatienne Blond (715795)
- Aadil El Turabi (715796)
- Lucy Beales (715797)
- Dean Clarke (715798)
- Robert J. C. Gilbert (205739)
- Elizabeth E. Fry (235531)
- David I. Stuart (29765)
- Kris Holmes (715799)
- Nicola J. Stonehouse (62738)
- Mike Whelan (715800)
- William Rosenberg (14858)
- George P. Lomonossoff (237550)
- David J. Rowlands (258522)
Publication date
April 2015
DOIAbstract
<p>a) The structure of a monomeric HBc VLP with one HBcAg dimer shown in a surface representation coloured yellow and green. b) Two HBcAg sequences fused together via a flexible linker makes a tandem core construct, with either full-length (hetero-tandem) or truncated (homo-tandem) C-terminus, and two modifiable major insertion regions (MIRs). c) Structure of a tandem core protein: N-terminal core 1 (in green) is fused via a flexible linker (red) to C-terminal core 2 (yellow). The two views are related by a 90° rotation.</p
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