iNKT cells are activated in the OVA-induced asthma model.

<p>A. The percentage of iNKT cells (PBS-57/CD1d⁺ TCR-β⁺) in lung MNCs. The gating used for iNKT cells (gate D) and the corresponding percentages are shown in each dot plot. <b>B</b>. Percentage of iNKT cells in lung MNCs from OVA-induced asthmatic mice and WT mice. N = 5 per group and **<i>P</i> < 0.01. <b>C</b>. Lung iNKT cells producing IFN-γ and IL-4. PBS-57/CD1d and TCR-β double-positive cells were examined for IFN-γ (top) and IL-4 (bottom) secretion. Numbers in each dot plot indicate the percentage of positive cells. <b>D</b>. Percentage of IFN-γ- and IL-4-expressing lung iNKT cells. N = 5 per group. *<i>P</i> < 0.05, **<i>P</i> < 0.01.