Behaviour effects by naloxone (nx) precipitated morphine withdrawal.

<p>We have evaluated the somatic signs: A) jumping, B) rearing; C) rubbing, D) grooming, E) Diarrhoea, and F) Freezing behavior induced after naloxone (1 mg/kg, s.c.)-injection to morphine or saline- treated mice during 18 min. We have also evaluated the time to first immobilization (G). Data are expressed as the mean ± SEM. *<i>p<</i>0.05,***<i>p<</i>0.001 versus WT mice treated with saline+nx; +<i>p<</i>0.05, ++<i>p<</i>0.01, +++<i>p<</i>0.001 versus KO mice treated with saline+nx; &<i>p<</i>0.05, &&<i>p<</i>0.01, &&&<i>p<</i>0.001 versus WT mice treated with morphine+nx; ##<i>p<</i>0.01, ###<i>p<</i>0.001 versus WT mice treated with saline+nx; $<i>p<</i>0.05, $$<i>p<</i>0.01 versus male of WT mice treated with saline+nx; çp<0.05 versus female of KO mice treated with morphine+naloxone.