Distribution of 15-mer T-cell epitopes and frequency of recognition over the HTNV-Gn/Gc full sequence.

<p>Each <i>bar</i> represents a distinctive HTNV-Gn/Gc T-cell epitope, with the length of the <i>bar</i> indicating the percentage of subjects targeting this epitope. <i>Bars</i> above the line correspond to responses at acute stage in the cohort with mild or moderate infection (n = 31), and the <i>bars</i> below the line represent responses detected in acute phase in persons with severe or critical infections (n = 39). The 20 epitopes with the start amino acid number of each peptide indicated were defined as the immunodominant epitopes, which were frequently recognized (≥10% of the total positive responding subjects, n = 70) in the patients. aa, amino acid.