Functional connectivity and amplitude of low frequency fluctuations group results.

<p>Group-level <i>t</i>-statistic maps showing significantly detectable FC (upper panel) and ALFF (lower panel) in the full-band frequency range. The three groups of subjects, HC, MCI and AD patients, are reported from left to right. Hot and cold colors encode for positive and negative group effect, respectively. Results were obtained via one-sample, two-tailed, t-tests (|t| > 3.7; p<0.05, corrected). Of note, despite it is expected to find negative ALFF values in white matter [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120988#pone.0120988.ref008" target="_blank">8</a>], this effect was striking in our results and it is primarily caused by the CompCor approach for noise mitigation [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120988#pone.0120988.ref035" target="_blank">35</a>]. The numbers next to the images refers to z coordinates in the MNI space. R, right; L, left.