Influence of ghrelin treatment (0.5 μg/g BW, twice a day, intraperitoneal (ip.)) on inflammatory mediators after cecal ligation and puncture (CLP)-induced sepsis.

<p>Serum was collected from control mice (ghrelin: n = 5–9/timepoint, untreated: n = 4–5/timepoint) and high fat diet (hfd) mice (ghrelin: n = 4–10/timepoint, untreated: n = 4–5/timepoint) before, 6h, 24h and 48h following CLP. Serum leptin levels of (A) control and (B) hfd mice, Interleukin (IL)-1ß levels of (C) control and (D) hfd mice and tumor necrosis factor (TNF)α levels of (E) control and (F) hfd mice were determined by ELISA (combined data from several independent experiments); * p < 0.05 of two-way ANOVA for unmatched samples followed by a <i>post hoc</i> Bonferroni test for analyses between more than two groups or within groups over time. All values are expressed as means ± SEM.