IL-17C^-/- and IL-17RE^-/- mice are resistant to systemic candidiasis.

<p><b>A-C.</b> IL-17RE^-/- and IL-17RE^+/+ littermate controls were subjected to systemic candidiasis by tail vein injection of 2x10⁵ C. albicans strain SC5314 (IL-17RE^+/+ n = 11; IL-17RE^-/-, n = 13; IL-17C^+/+; n = 10; IL-17C^-/- n = 11). Mice were evaluated daily and time to sacrifice is presented. ns., not significant. Data are representative of 2 independent experiments. <b>C-D.</b> IL-17RE^-/- mice (n = 7) and IL-17C^-/- (n = 5) mice were injected with 1x10⁵ cells C. albicans as in panel A. WT littermates (IL-17C^+/+, n = 4 and IL-17RE^+/+, n = 5) and IL-17RA^-/- mice (n = 5) served as controls. ns., not significant. Data are representative of one independent experiment. <b>E.</b> Weight change assessments were made in all cohorts after infection with 2x10⁵ C. albicans cells, and presented as a percentage of starting weight. <b>F.</b> Kidneys were harvested from each cohort on day 2 after systeic infection and qperformed for the indicated genes. *p<0.05 by ANOVA and post-hoc Tukey’s test. <b>G.</b> Indicated tissue types were harvested on day 2 and tissue fungal burdens determined. Each data point represents one mouse. (IL-17RE^+/+ Sham, n = 3; IL-17RE^-/- Sham, n = 2; IL-17RE^+/+ n = 9; IL-17RE^-/- n = 10). Pooled data from two independent experiments is shown.