True Positive Rate (TPR) vs. False Discovery Rate (FDR) plots for the six DE test methods performed on RNA-Seq datasets simulated to mimic real datasets.

<p>The fold changes of DE genes are fixed at 1.5 (half of the DE genes are over-expressed and the other half are under-expressed). Other simulation settings are identical to those described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120117#pone.0120117.g002" target="_blank">Fig. 2</a> legend.