Analysis of microarray datasets from CML CD34+ patients and NBM donors.

<p><b>(a)</b> Shows PCA plots of three gene expression datasets from the GSE library. Datasets comprise gene expression profiles of CD34+ haematopoietic stem cells from normal donors (n = 14), donors in chronic phase of CML (n = 15), donors treated with seven days of IM following a diagnosis of chronic phase CML (n = 6), and donors treated with IM for a median duration of 28 months (range 11–39 months) (n = 8). To identify the role of Notch signalling in chronic phase CML and following treatment with IM, gene set enrichment analysis was performed by comparing 14 bone marrow samples from normal subjects with 6 paired samples obtained from chronic phase CML patients before IM and after 7 days of IM treatment. <b>(b)</b> Shows regulation of genes involved in Notch signalling pre- and post-IM and its correlation with cell cycle pathways and DNA replication pathways.