Correlations between A-syn levels in CSF and plasma samples obtained at the same time.

<p>Scatter plots of A-syn levels in CSF versus plasma in the PD group (A), control group (B), and the combination of PD patients and the controls (C). Closed and open circles indicate samples from the PD and the control groups, respectively. The solid lines indicate regression analyses. There was a significant positive correlation in the PD group (A) (p = 0.005). In the control group (B), no significant correlation was observed (p = 0.50). Dashed lines in (C) indicate the mean values of CSF (29.07 ng/ml) and plasma (31.72 ng/ml) A-syn in the controls, and are plotted to clarify the discrepancy between the PD and control groups with respect to the relationship between CSF and plasma A-syn levels. There was a tendency for patients whose CSF A-syn levels were lower than 29.07 ng/ml to exhibit plasma A-syn levels less than 31.72 ng/ml in the PD group (closed circles, Fig 5C); however, no such a tendency was observed in the control group (open circles, Fig 5C).