TAK242 reduced ApoA1-induced IL-6, MMP-1 and MMP-3 expressions in human primary chondrocytes and fibroblast-like synoviocytes (FLS).

<p>A) Primary human Chondrocytes and B) FLS were stimulated with ApoA1 (30μg/mL) in the presence or not of several inhibitors: lipoxin A4 (LX4; 1μM), anti-SR-B1 antibody (5μg/mL) and its isotype IgG1 control antibody (5μg/mL), anti-RAGE (10μg/mL) and its isotype IgG control antibody (10μg/mL) and TAK242 (1μM) for FPRL1, SR-B1, RAGE and TLR4 receptors, respectively. Polymyxin B was used at a concentration of 1μg/mL. *b and *h statistically different to “a” and “g”, respectively. Data were expressed as the means ± SEM (n = 3). * P< 0.05 by Mann–Whitney test.