Schematic representation of human PHF8 together with its <i>C</i>. <i>elegans</i> homologs, and a simplified gene structure of <i>C</i>. <i>elegans jmjd-1</i>.<i>1</i>.

<p>(A) Comparison of the amino acid sequences of human histone demethylase PHF8 and its <i>C</i>. <i>elegans</i> homologs. The alignment of conserved domains and similarity scores were obtained using NCBI Protein Blast. (B) The structure of <i>C</i>. <i>elegans jmjd-1</i>.<i>1</i> (F43G6.6), from exon 1 to 7 (black boxes), and the deletion site in the allele <i>tm3980</i>.