Conditional SAE knockdown delays tumor progression.
- Xingyue He (720471)
- Jessica Riceberg (720472)
- Sai M. Pulukuri (720473)
- Steve Grossman (720474)
- Vaishali Shinde (653695)
- Pooja Shah (720475)
- James E. Brownell (720476)
- Larry Dick (720477)
- John Newcomb (720478)
- Neil Bence (720479)
Publication date
April 2015
DOIAbstract
<p>(A) HCT116 cells infected with Dox inducible SAE2 shRNAs were injected subcutaneously in immunocompromised mice. Dox treatment starts at D14 after injection (set as D0). Error bars denote s.d. (n = 4). (B) SAE2 shRNA reduced SUMO pathway activity in tumors. Protein lysates from tumors were immunoblotted with indicated antibodies. (C) Whole-body fluorescent imaging of mice untreated or treated with Dox. Color bar denotes signal intensity.</p
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