Box plots of sCD163, CXCL13, NEO, NfL, and OPN.

<p>Fig 2 shows box plots of all biomarkers including CSF and serum concentrations as well as ratios and index values. The box plots show levels of all the parameters for each group, RRMS, PPMS, CIS and SC. The horizontal line in each box is the median, whiskers fences the upper and lower quartiles. The data on sCD163 have previously been presented in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119681#pone.0119681.ref018" target="_blank">18</a>]. Fig 2a–2d shows the values for sCD163, Fig 2e–2h shows the values for CXCL13, Fig 2i–2l shows the values for NEO, Fig 2m shows the values for NfL CSF, and Fig 2n–2qshows the values for OPN. For all biomarkers, there were some overlaps in levels between patient groups, and symptomatic controls. Abbreviations: RRMS (relapsing-remitting MS), PPMS (primary-progressive MS), CIS (clinically isolated syndrome), SC (symptomatic controls), CSF (cerebrospinal fluid), sCD163 (soluble CD163), NEO (neopterin), NfL (neurofilament light polypeptide), OPN (osteopontin).