TLR-3 deficiency does not ameliorate adipose tissue inflammation.
- Dov B. Ballak (526628)
- Edwin J. P. van Asseldonk (720953)
- Janna A. van Diepen (526630)
- Henry Jansen (526631)
- Anneke Hijmans (526632)
- Leo A. B. Joosten (195019)
- Cees J. Tack (345136)
- Mihai G. Netea (105648)
- Rinke Stienstra (24050)
Publication date
April 2015
DOIAbstract
<p>After 16 weeks of low fat diet (LFD) or high fat diet (HFD) intervention, adipose tissue of wild-type (WT) and TLR-3-/- mice was investigated for inflammatory parameters. (a) Adipose tissue of mice stained for F4/80, magnification 20x, (b) number of crown-like structures in adipose tissue. Inflammatory markers were measured (c) F480, (d) CD68, (e) MCP-1, (f) TNFα, (g) CXCL1. (h) mRNA levels of TLR-3 in WT mice fed a LFD or HFD for 16 weeks. * p<0.05, ** p<0.01. Number of mice per group: WT-LFD n = 10; WT-HFD n = 10; TLR-3-/-LFD n = 7; TLR-3-/-HFD n = 9. Data are shown as means ± SEM.</p
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