Multiple sequence alignment of DiACT with homologous proteins.

<p>Alignment of the <i>D</i>. <i>immitis</i> ACT sequence (I3WTW3) with the ACT from <i>W</i>. <i>bancrofti</i> (EJD75047), <i>O</i>. <i>volvulus</i> (EJW73626), <i>B</i>. <i>malayi</i> (P48812), <i>L</i>. <i>loa</i> (O01360), <i>Ascaris suum</i> (BAB68543), <i>Homo sapiens</i> (P20287) and <i>S</i>. <i>bovis</i> (AIE44418). The percentage of sequence identity between <i>D</i>. <i>immitis</i> sequence and the others is indicated. The amino acids conserved in all the sequences are labelled with asterisks, and conservative and semiconservative substitutions are respectively labelled with two and one point. Conserved lysine residues are shaded in yellow. The PLG-binding domain (GDEAQSKRGILTLKY) are shaded in grey.