IL-1β and TNF-α secretion.
- Diana Aguirre-Rueda (721654)
- Sol Guerra-Ojeda (721655)
- Martin Aldasoro (721656)
- Antonio Iradi (721657)
- Elena Obrador (559979)
- Maria D. Mauricio (721658)
- Jose Mª Vila (721659)
- Patricia Marchio (721660)
- Soraya L. Valles (559980)
Publication date
April 2015
DOIAbstract
<p>WIN prevents the increase of IL-1β and TNF-α secretion caused by Aβ<sub>1–42</sub> in astrocytes. Cells were incubated with 10 μM Aβ<sub>40–1</sub> (control peptide, C), 10 μM Aβ<sub>1–42</sub> (Aβ), 10 μM WIN + 10 μM control peptide (WIN) and 10 μM WIN + 10 μM Aβ<sub>1–42</sub> (WIN + Aβ). Cell culture supernatants were harvested, and IL-1β (panel A) and TNF-α (panel B) secretion were determined by ELISA. Values are means ± SD of replicate experiments from 4 independent astrocytes cultures. *<i>p</i><0.05 <i>vs</i> control astrocytes. #<i>p</i><0.05 <i>vs</i> Aβ<sub>1–42</sub> treated cells.</p