MyD88-dependent signaling is crucial for systemic inflammation observed in mFADD^-/- mice.

<p><b>A.</b> Spleen weights of mFADD^-/-MyD88^-/- mice, their MyD88^-/- littermates and age-matched mFADD^-/- and their wild-type littermate controls (Ctl). <b>B-D.</b> Cell numbers of neutrophils (Nφ), macrophages (Mφ), and inflammatory monocytes (IM) in the spleens of mFADD^-/-MyD88^-/- mice as compared to their MyD88^-/- littermates, aged-matched mFADD^-/- mice and wild-type controls (Ctl). Each open or closed circle, triangle or box represents one mouse. ***p<0.001, **p<0.01, *p<0.05.