Effects of reagents that affect epigenetic modification on progressive hearing loss in DBA mice.

<p>ABR threshold increases at 8, 16, and 32 kHz in DBA mice from 4 to 12 weeks of age that were treated with different reagents. Values shown are the mean ± s.d.; *<i>p</i> < 0.05, **<i>p</i> <0.01 (one-way ANOVA and Scheffe’s test). The numbers of animals in each group were as follows: 5 for untreated (unt), 19 for control (ctrl), 21 for M+V, 10 each for MET and VPA, and 11 each for FA and VB12. SPL, sound pressure level.