Trichoharzianol, a New Antifungal from Trichoderma harzianum F031

A new decalin derivative, trichoharzianol (<b>1</b>), together with three known compounds, eujavanicol A (<b>2</b>), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (<b>3</b>), and 4,6-dihydroxy-5-methylphthalide (<b>4</b>), were isolated from Trichoderma harzianum F031. For the first time, compounds <b>2</b>–<b>4</b> were reported from the Trichoderma species. Their structures were characterized by spectroscopic methods. Trichoharzianol (<b>1</b>) showed the highest antifungal activity against Colletotrichum gloeosporioides, with a minimum inhibitory concentration (MIC) of 128 μg/mL