Subcellular localization of Ala-scanning PTEN mutations on a PTEN 1–403 background.

<p><b>*</b>Percentage of COS-7 cells showing nuclear (N), cytoplasmic (C), or nuclear/cytoplasmic staining (N/C) is indicated. Note that, in the context of PTEN 1–403, most of the mutations did not affect the localization of PTEN wild type (wt), with the exception of some mutations in the cytoplasmic localization signal at residues 19–25, which favored PTEN 1–403 nuclear accumulation</p><p>Subcellular localization of Ala-scanning PTEN mutations on a PTEN 1–403 background.