Evaluation of the diagnostic performance of candidate serum biomarkers AGR3, AGR2 and their combination.

<p>Scatter plot demonstrating a highly significant elevation of (<b>A</b>) AGR3 and (<b>C</b>) AGR2 protein concentration in human serum samples from breast cancer patients (n = 40) in comparison with samples from healthy women (n = 40). ROC curve analysis for (<b>B</b>) AGR3, (<b>D</b>) AGR2 and (<b>E</b>) the combination of both proteins. ** <i>P</i> < 0.01, *** <i>P</i> < 0.001. ROC: receiver operating characteristic, AUC: area under the curve, 95% CI: 95% confidence interval.