p53^R172H does not result in gain-of-function properties in an HCC mouse model.

<p>A) Kaplan-Meier curve displaying tumor free survival of p53^fl/fl and p53^R172H littermates. Mice were assessed over a period of 9 months and sacrificed when illness was apparent. Only mice whose death was perceived to be due to HCC were included, otherwise the mouse was censored. Censored animals are represented in the figure as tick marks on the day of death. B) Total tumor burden in the survival cohort. Individual tumor volume was calculated using the formula for an ellipsoid. All of the tumor volumes for a given mouse were summed to arrive at the tumor burden per animal. C) H&E staining demonstrating commonly seen architecture in HCC mouse model. D) Number of p53^R172H and p53^fl/fl mice with (grey) or without (black) grossly visible metastatic lesions.