Volcano plot and unsupervised hierarchical clustering of differentially expressed miRNAs in the small airway epithelium (SAE) of healthy smokers and healthy nonsmokers.

<p>A. Volcano plot comparing the expression of 1100 human mature miRNAs in the SAE of smokers <i>vs</i> nonsmokers. There were 25 miRNAs (red) upregulated and 9 miRNAs (blue) downregulated in the SAE of healthy smokers compared to healthy nonsmokers (fold-change >1.5, p<0.01, total 34 miRNAs). X-axis, fold-change; Y-axis, p values. B. Unsupervised hierarchical clustering of 34 differentially expressed miRNAs between healthy smokers (tan rectangle) and healthy nonsmokers (green rectangle). The color bar indicates the relative miRNA expression level.