<p>(<b>A</b>) Intracellular survival of <i>Mtb</i> strains. Macrophages were infected with <i>Mtb</i> strains for 3 hours, followed by 0 or 72-hour chase. CFUs were counted after 4–5 weeks of growth at 37°C. Bars represent percentages of CFUs remaining at 72-hour compared to 0-hour time point. Error bars represent standard deviations from 3–6 repeats. *, p < 0.001; ns, not significant relative to <i>Mtb</i> H37Rv; #ns, not significant between the two indicated groups. Order of strains is as in 7B. (<b>B</b>) Quantitative analysis of lysosomal delivery following phagocytosis of <i>Mtb</i> strains by macrophages. Macrophages were infected with FLUOS-stained <i>Mtb</i> strains for 1 hour, followed by 16-hour chase. Infected macrophages (see C ...
AbstractElucidating virulence effectors important for M. tuberculosis survival in the host macrophag...
Tuberculosis (TB) remains a major public health issue worldwide. Global TB control efforts are signi...
<div><p>The intracellular pathogen <i>Mycobacterium tuberculosis</i> (Mtb) is constantly exposed to ...
A key to the pathogenic success of Mycobacterium tuberculosis (Mtb), the causative agent of tubercul...
The success of M. tuberculosis lies in its ability to stay alive and persist in a potentially hostil...
<div><p>A key to the pathogenic success of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), the causa...
<p>THP-1-derived macrophages were infected with Mtb<i><sub>Pptr</sub>eccB<sub>5</sub>-eccC<sub>5</su...
Intracellular pathogens such as Mycobacterium tuberculosis have evolved strategies for coping with t...
<div><p>Survival of <i>M</i>. <i>tuberculosis</i> in host macrophages requires the eukaryotic-type p...
<div><p>Intracellular pathogens such as <em>Mycobacterium tuberculosis</em> have evolved strategies ...
<div><p>Defining the mechanisms of <i>Mycobacterium tuberculosis</i> (Mtb) persistence in the host m...
<p>THP-1 cells infected with <i>Mtb</i> H37Rv expressing Mrx1-roGFP2 were treated with ETH (5 µg/ml)...
Tuberculosis kills an estimated 2 million people each year. The causative organism, Mycobacterium tu...
Macrophages play an essential role in the immune system by ingesting and degrading invading pathogen...
Mycobacterium tuberculosis (Mtb) is the bacterium responsible for tuberculosis (TB). For decades, it...
AbstractElucidating virulence effectors important for M. tuberculosis survival in the host macrophag...
Tuberculosis (TB) remains a major public health issue worldwide. Global TB control efforts are signi...
<div><p>The intracellular pathogen <i>Mycobacterium tuberculosis</i> (Mtb) is constantly exposed to ...
A key to the pathogenic success of Mycobacterium tuberculosis (Mtb), the causative agent of tubercul...
The success of M. tuberculosis lies in its ability to stay alive and persist in a potentially hostil...
<div><p>A key to the pathogenic success of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), the causa...
<p>THP-1-derived macrophages were infected with Mtb<i><sub>Pptr</sub>eccB<sub>5</sub>-eccC<sub>5</su...
Intracellular pathogens such as Mycobacterium tuberculosis have evolved strategies for coping with t...
<div><p>Survival of <i>M</i>. <i>tuberculosis</i> in host macrophages requires the eukaryotic-type p...
<div><p>Intracellular pathogens such as <em>Mycobacterium tuberculosis</em> have evolved strategies ...
<div><p>Defining the mechanisms of <i>Mycobacterium tuberculosis</i> (Mtb) persistence in the host m...
<p>THP-1 cells infected with <i>Mtb</i> H37Rv expressing Mrx1-roGFP2 were treated with ETH (5 µg/ml)...
Tuberculosis kills an estimated 2 million people each year. The causative organism, Mycobacterium tu...
Macrophages play an essential role in the immune system by ingesting and degrading invading pathogen...
Mycobacterium tuberculosis (Mtb) is the bacterium responsible for tuberculosis (TB). For decades, it...
AbstractElucidating virulence effectors important for M. tuberculosis survival in the host macrophag...
Tuberculosis (TB) remains a major public health issue worldwide. Global TB control efforts are signi...
<div><p>The intracellular pathogen <i>Mycobacterium tuberculosis</i> (Mtb) is constantly exposed to ...