<p>(A, B) TP53 mutational status was evaluated by immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissues. Dot plots represent miR-34a/b/c threshold cycle values of tumor tissue from TaqMan qRT-PCR normalized to U66 in American cohort (A) and Chinese cohort (B). Horizontal bars indicate median expression value. Mann-Whitney test was used. WT: wild-type p53, Mut: mutant p53.</p
p53 (TP53) is the most commonly mutated tumor suppressor in cancer. How mutant forms of p53 can cont...
Abstract Background Mutations in the TP53 gene are ex...
Aim: Tumour suppressor gene p53 is a common target in carcinogenesis, reported to be altered and fun...
<p><b>(A)</b> Sequence of the miR-34a region in chromosome 1 in miR-34a-KO MCF7 cells compared to WT...
<p><b>(A)</b> Sequence of the miR-34a region in chromosome 1 in miR-34a-KO HCT116 cells compared to ...
Mutation and/or loss of the TP53 tumour suppressor gene is the single most common genetic abnormalit...
Many human cancers contain missense TP53 mutations that result in p53 protein accumulation. Although...
<p>(A, B) Dot plots represent miR-34a/b/c threshold cycle values from TaqMan qRT-PCR normalized to U...
<p>RNA samples from cancer epithelium, cancer stroma, normal adjacent epithelium and normal adjacent...
<p><b>(A)</b><i>TP53</i> mRNA is enriched in Bi-miR-34a PDs in HCT116 cells. mRNA levels were determ...
The initial observation that p53 accumulation might serve as a surrogate biomarker for TP53 mutation...
International audienceThe TP53 tumor suppressor gene is frequently mutated in human cancers. An anal...
Accumulation of p53 protein resulting in levels detectable by immunohistochemistry (IHC) has been pr...
BACKGROUND: The p53 tumor suppressor gene is mutated in a large percentage of human malignancies, in...
Although evidence suggests an inverse relationship between microsatellite instability and p53 altera...
p53 (TP53) is the most commonly mutated tumor suppressor in cancer. How mutant forms of p53 can cont...
Abstract Background Mutations in the TP53 gene are ex...
Aim: Tumour suppressor gene p53 is a common target in carcinogenesis, reported to be altered and fun...
<p><b>(A)</b> Sequence of the miR-34a region in chromosome 1 in miR-34a-KO MCF7 cells compared to WT...
<p><b>(A)</b> Sequence of the miR-34a region in chromosome 1 in miR-34a-KO HCT116 cells compared to ...
Mutation and/or loss of the TP53 tumour suppressor gene is the single most common genetic abnormalit...
Many human cancers contain missense TP53 mutations that result in p53 protein accumulation. Although...
<p>(A, B) Dot plots represent miR-34a/b/c threshold cycle values from TaqMan qRT-PCR normalized to U...
<p>RNA samples from cancer epithelium, cancer stroma, normal adjacent epithelium and normal adjacent...
<p><b>(A)</b><i>TP53</i> mRNA is enriched in Bi-miR-34a PDs in HCT116 cells. mRNA levels were determ...
The initial observation that p53 accumulation might serve as a surrogate biomarker for TP53 mutation...
International audienceThe TP53 tumor suppressor gene is frequently mutated in human cancers. An anal...
Accumulation of p53 protein resulting in levels detectable by immunohistochemistry (IHC) has been pr...
BACKGROUND: The p53 tumor suppressor gene is mutated in a large percentage of human malignancies, in...
Although evidence suggests an inverse relationship between microsatellite instability and p53 altera...
p53 (TP53) is the most commonly mutated tumor suppressor in cancer. How mutant forms of p53 can cont...
Abstract Background Mutations in the TP53 gene are ex...
Aim: Tumour suppressor gene p53 is a common target in carcinogenesis, reported to be altered and fun...