Changes in cytokine responses to E6C10 over 12 months in patients.

<p>IFN-γ (a), TNF-<b>α</b> (b) and IL-10 (c) responses to E6C10 in patients at baseline, 6 and 12 months following whole blood stimulation with E6C10 for 48 hours. Filled circles represent baseline levels, filled diamonds represent 6 month levels and filled triangles represent 12 month levels. Results are individual responses and cytokine levels are expressed as log₁₀ pg/ml. Horizontal bars are medians. Freidman test with Dunn’s multiple comparisons was used to compare cytokine levels overtime.