Changes in TNF-α response to Rv2031 over 12 months in patients and contacts.

<p>TNF-α response over 12 months in patients (a) and contacts (b) following whole blood stimulation with Rv2031 for 48 hours. Filled circles represent baseline levels, filled diamonds represent 6 month levels and filled triangles represent 12 month levels. Results are individual responses and cytokine levels are expressed as log₁₀ pg/ml. Horizontal bars are medians. Freidman test with Dunn’s multiple comparisons was used to compare TNF-α response over time. ***p<0.001, ****p<0.0001.