Involvement of neuronal calcium sensor-1 in IP₃R-dependent Ca²⁺ release in cardiomyocytes.

<p>Comparison of the effects of IGF-1 stimulation on cytoplasmic and nuclear Ca²⁺ levels between wild type (WT) and neuronal calcium sensor-1 (NCS-1) deficient (KO) NMVMs. (A–D) Representative traces and averaged data of the peak fluorescence intensity (F/F₀) of cytoplasmic and nuclear Ca²⁺ transients. n = 25 for WT and 37 for KO. (E and F) Summarized data obtained from the concentration-dependent experiments analyzing cytoplasmic and nuclear Ca²⁺ transients induced by 1, 3, and 30 nmol/L IGF-1. n = 11–30, **<i>P</i> < 0.01 vs. WT; values are expressed as means ± SEM.