The effect of the CAN current in a network model with a feedback inhibition.

<p>(A1 and 2) Responses of the pure network model with different inhibitory synaptic conductances: 0.007 and 0.03 nS, respectively. (B1 and 2) Responses of the hybrid network model with different inhibitory synaptic conductances: 0.007 and 0.03 nS, respectively. (C) The model network structure. <i>White circles</i> represent pyramidal cells and <i>shaded circles represent</i> inhibitory cells. (D—F) Frequency of persistent firing as a function of the inhibitory synaptic conductance (Wip), with different time constants for IPSC: 5 ms, 50 ms and 250 ms, respectively. Frequency of persistent firing is modulated gradually by the increased inhibitory conductance in the hybrid model with the CAN current but not in the pure network model.