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<i>H</i>. <i>ducreyi</i> PEA transferases confer resistance to α- and β-defensins.

  • Michael P. Trombley (728690)
  • Deborah M. B. Post (160644)
  • Sherri D. Rinker (728691)
  • Lorri M. Reinders (728692)
  • Kate R. Fortney (728693)
  • Beth W. Zwickl (728694)
  • Diane M. Janowicz (728695)
  • Fitsum M. Baye (728696)
  • Barry P. Katz (166443)
  • Stanley M. Spinola (728697)
  • Margaret E. Bauer (728698)
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Publication date
April 2015
Icon DOI
10.1371/journal.pone.0124373.g002

Abstract

<p>35000HP, 35000HPΔPEAT and 35000HPΔPEAT/pPEAT were tested for resistance to the (A) α-defensin HD-5 (B) β-defensin HBD-3, and (C) human cathelicidin LL-37. Asterisks indicate statistically significant differences from 35000HP (<i>P</i> < 0.05). Complementation with pPEAT restored parental levels of susceptibility to defensins. Data represent average ± standard error of six independent replicates, and statistical significance was determined by Student’s t-test.</p

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