Inhibition of p38 abrogates the protective effect of RP-220.

<p>A, Inhibition of either p38 (SB203580) or ERK (U0126) did not adversely affect the survival of HK-2 cells measured using the WST-1 method; cell survival is depicted as % change in survival compared to that of untreated HK-2 cells; n = 4, * = P<0.05. B, Inhibition of p38 (10 μM SB203580)abrogated the protective action of RP-220 for HK-2 cells exposed to 20 μM cisplatin (Cis) for 24 hrs; n = 4, * = P<0.05.