Induction of H3-Pser-10 is dependent in p38α MAPK and IKK-2 signalling.
- John A. Marwick (728924)
- Corina Tudor (728925)
- Nadia Khorasani (728926)
- Charalambos Michaeloudes (728927)
- Pankaj K. Bhavsar (728928)
- Kian F. Chung (728929)
Publication date
April 2015
DOIAbstract
<p>Panel A shows the expression of H3-Pser10 measured by western blot from blood monocytes from a healthy normal subject induced by H<sub>2</sub>O<sub>2</sub> and LPS, and the effect of the p38α MAPK inhibitor SB239063 and the IKK-2 inhibitor TPCA-1. Panel B shows the concentration dependent reduction of LPS-induced H3-Pser10 expression by SB239063 and TPCA-1. Panel C shows the reduction of LPS-induced H3-Pser10 by siRNA knockdown of p38α MAPK, MSK-1 and IKK-2 protein expression but not by knockdown of MSK-2 or IKK-1 protein expression.</p
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