Ischemic brain damage induces the degradation of drebrin A.

<p>(a) Image of a mouse coronal brain slice showing the site of induction of photothrombotic ischemia (red) at the right hemisphere. The left hemisphere was used as a control. (b) Western blot analyses of drebrin A in total protein extracts of the left hemisphere (control) and the ischemic right hemisphere of the mouse brain. The DAS2 antibody was used to detect full-length drebrin A and its degradation products. The expression level of GAPDH was used as a loading control. The experiment was repeated three times with similar results.