LNA <i>in situ</i> hybridization-based analysis of miR-193b in PDAC and matched adjacent benign tissues.

<p>(A) Negative control staining (scramble probe) of benign pancreas. To reveal structural details, this negative control was further stained with nuclear fast red (inset); islet (arrow) and ductal (*) cells are indicated. (B) Positive control (U6 probe) showing nuclear staining of all cells; islet (arrow) and ductal (*) cells are indicated. (C, D) Adjacent benign tissues showing strong positive miR-193b signals in acinar cells, but only weaker positive signals in islet (arrow) and ductal (*) cells. (E, F) A representative PDAC sample showing moderately positive (2+) labeling for miR-193b. (G, H) Another PDAC sample showing weakly positive (1+) labeling for miR-193b. D, F and H are four-fold zoom outs of C, E and G, respectively. Each horizontal bar represents 500 μm.