Effects of LL-23, LL-23V9 or GI-20 on replication of Cal09 or NY01 in various cell types.

<p>All of the peptides caused significant inhibition of NY01 in MDCK cells and HBTE cells. For SAE cells LL-23V9 and GI-20 caused significant inhibition for NY01 but LL-23 did not. GI-20 caused significant inhibition of Cal09 in all three cell types. LL-23 and LL-23V9 caused modest but statistically significant inhibition of Cal09 in MDCK cells but not in HBTE or SAE cells. LL-23 (11μM) caused significant increase in replication of Cal09 in SAE cells. Results are mean±SEM of 4 or more experiments. * indicates a significant decrease in viral foci (p<0.05) compared to control. ** indicates a significant increase in viral foci (p<0.01) compared to control.