Pharmacological distribution diagram for Akt inhibitors obtained using the DF2 (the black colour represents Akt inhibitors and the white colour, the compounds without Akt inhibition activity).

Diagram showing the depressant action of H2 receptor antagonists.

Shuang Zhang (117657)
Zhiwei Xu (294494)
Yan Gao (93649)
Yonghong Wu (294495)
Zhihui Li (294496)
Haifeng Liu (117312)
Chenggang Zhang (294498)

February 2013

Diagram showing the depressant action of H2 receptor antagonists.</p

Schematic illustration of different inhibition mechanisms and the associated DSF signatures: A) GSH-competitive inhibition; B) conjugate-formation; C) ligandin-type.

Wendy A. Lea (167535)
Anton Simeonov (85099)

April 2012

Schematic illustration of different inhibition mechanisms and the associated DSF signatures: A) G...

Protein kinase inhibitors

Xerxa, Elena
Miljković, Filip
Bajorath, Jürgen

May 2023

The deposition contains data sets of human and mouse protein kinase inhibitors with reliable activit...

Pharmacological distribution diagram for natural Akt inhibitors obtained using the DF1 (the black colour represents Akt inhibitors and the white colour, the compounds without Akt inhibition activity).

Riccardo Zanni (729628)
Maria Galvez-Llompart (729629)
Cecilia Morell (729630)
Nieves Rodríguez-Henche (729631)
Inés Díaz-Laviada (729632)
Maria Carmen Recio-Iglesias (729633)
Ramon Garcia-Domenech (729634)
Jorge Galvez (543448)

April 2015

Pharmacological distribution diagram for natural Akt inhibitors obtained using the DF1...

Pharmacological distribution diagram for β-catenin inhibitors obtained using the DF4 (the black color represents β-catenin inhibitors and the white color, the compounds without β-catenin inhibition activity).

Riccardo Zanni (729628)
Maria Galvez-Llompart (729629)
Cecilia Morell (729630)
Nieves Rodríguez-Henche (729631)
Inés Díaz-Laviada (729632)
Maria Carmen Recio-Iglesias (729633)
Ramon Garcia-Domenech (729634)
Jorge Galvez (543448)

April 2015

Pharmacological distribution diagram for β-catenin inhibitors obtained using the DF4 (...

Pharmacological distribution diagram for natural β-catenin inhibitors obtained using the DF3 (the black color represents natural β-catenin inhibitors and the white color, the compounds without β-catenin inhibition activity).

Riccardo Zanni (729628)
Maria Galvez-Llompart (729629)
Cecilia Morell (729630)
Nieves Rodríguez-Henche (729631)
Inés Díaz-Laviada (729632)
Maria Carmen Recio-Iglesias (729633)
Ramon Garcia-Domenech (729634)
Jorge Galvez (543448)

April 2015

Pharmacological distribution diagram for natural β-catenin inhibitors obtained using the DF3...

Experimental versus predicted inhibitory potency (log(1/IC50)) values of quinoline type inhibitors of Akt2.

Noreen Akhtar (3609425)
Ishrat Jabeen (1284885)

December 2016

The data points in square and circle represent training and test set compounds respectively.</p

Diagrammatic representation of PI3K/AKT/mTOR signalling pathway detailing tested drug targets and overall ranking table.

Temitope Sasore (619737)
Breandán Kennedy (619738)

August 2014

Upon activation by receptor tyrosine kinase, PI3K lipid kinases are recruited to the plasma membr...

Distribution of tested inhibitors across the kinome.

Matthew Ryals (516790)
Kwang Pak (405682)
Rahul Jalota (4524190)
Arwa Kurabi (344167)
Allen F. Ryan (405683)

October 2017

The inhibitor targets are indicated in red. The kinome diagram is adapted, with permission, from ...

Schematic diagram of avibactam inhibition and deacylation pathways of KPC-2.

Nikhil P. Krishnan (792291)
Nhu Q. Nguyen (792292)
Krisztina M. Papp-Wallace (792293)
Robert A. Bonomo (188763)
Focco van den Akker (158508)

September 2015

Schematic diagram of avibactam inhibition and deacylation pathways of KPC-2.</p

Schematic diagram showing the chemical structure and pharmacological effects of DMH1 and compound C on Akt and glucose metabolism.

Xin Xie (311744)
Xiao-Ming Xu (188852)
Na Li (6550)
Yong-Hui Zhang (573497)
Yu Zhao (104852)
Chun-Yan Ma (632913)
De-Li Dong (5660674)

September 2014

DMH1 activated Akt and increased glucose metabolism; but compound C inhibited DMH1 –induced Akt a...

Number distribution of therapeutic peptides.

Wenhui Yan (825510)
Wending Tang (9241764)
Lihua Wang (14548)
Yannan Bin (6286199)
Junfeng Xia (192875)

September 2022

The upset plot shows the detailed number of therapeutic peptides in each group. In the upset plot, t...

Distribution of compound activity.

Jessica E. Hutti (146243)
Melissa A. Porter (146246)
Adam W. Cheely (146252)
Lewis C. Cantley (105082)
Xiaodong Wang (66801)
Dmitri Kireev (146259)
Albert S. Baldwin (146265)
William P. Janzen (146268)

July 2012

A–B) The kinase library was screened at 10 µM in a single concentration format against enzymatic ...

Pharmacophore Modeling, Virtual Screening, and Mo- lecular Docking Studies for Discovery of Novel Akt2 Inhibitors

Jia Fei
Lu Zhou
Tao Liu
Xiang-yang Tang

November 2015

licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that th...

The schematic diagram of tissue distribution of Compound 1 in Wistar rats after 180/kg of orally administered Compound 1 (mean ± S.D., n = 6).

Juan Wang (115708)
Xiaofeng Qu (577153)
Yanfei Qi (577154)
Jinhua Li (160513)
Xiuling Song (577155)
Li Li (14993)
Dehui Yin (577156)
Kun Xu (116877)
Juan Li (146180)

June 2014

The schematic diagram of tissue distribution of Compound 1 in Wistar rats after 180/kg of orally ...

Diagram showing the depressant action of H2 receptor antagonists.

Shuang Zhang (117657)
Zhiwei Xu (294494)
Yan Gao (93649)
Yonghong Wu (294495)
Zhihui Li (294496)
Haifeng Liu (117312)
Chenggang Zhang (294498)

February 2013

Diagram showing the depressant action of H2 receptor antagonists.</p

Schematic illustration of different inhibition mechanisms and the associated DSF signatures: A) GSH-competitive inhibition; B) conjugate-formation; C) ligandin-type.

Wendy A. Lea (167535)
Anton Simeonov (85099)

April 2012

Schematic illustration of different inhibition mechanisms and the associated DSF signatures: A) G...

Protein kinase inhibitors

Xerxa, Elena
Miljković, Filip
Bajorath, Jürgen

May 2023

The deposition contains data sets of human and mouse protein kinase inhibitors with reliable activit...

Pharmacological distribution diagram for natural Akt inhibitors obtained using the DF1 (the black colour represents Akt inhibitors and the white colour, the compounds without Akt inhibition activity).

Riccardo Zanni (729628)
Maria Galvez-Llompart (729629)
Cecilia Morell (729630)
Nieves Rodríguez-Henche (729631)
Inés Díaz-Laviada (729632)
Maria Carmen Recio-Iglesias (729633)
Ramon Garcia-Domenech (729634)
Jorge Galvez (543448)

April 2015

Pharmacological distribution diagram for natural Akt inhibitors obtained using the DF1...

Pharmacological distribution diagram for β-catenin inhibitors obtained using the DF4 (the black color represents β-catenin inhibitors and the white color, the compounds without β-catenin inhibition activity).

Riccardo Zanni (729628)
Maria Galvez-Llompart (729629)
Cecilia Morell (729630)
Nieves Rodríguez-Henche (729631)
Inés Díaz-Laviada (729632)
Maria Carmen Recio-Iglesias (729633)
Ramon Garcia-Domenech (729634)
Jorge Galvez (543448)

April 2015

Pharmacological distribution diagram for β-catenin inhibitors obtained using the DF4 (...

Pharmacological distribution diagram for natural β-catenin inhibitors obtained using the DF3 (the black color represents natural β-catenin inhibitors and the white color, the compounds without β-catenin inhibition activity).

Riccardo Zanni (729628)
Maria Galvez-Llompart (729629)
Cecilia Morell (729630)
Nieves Rodríguez-Henche (729631)
Inés Díaz-Laviada (729632)
Maria Carmen Recio-Iglesias (729633)
Ramon Garcia-Domenech (729634)
Jorge Galvez (543448)

April 2015

Pharmacological distribution diagram for natural β-catenin inhibitors obtained using the DF3...

Experimental versus predicted inhibitory potency (log(1/IC50)) values of quinoline type inhibitors of Akt2.

Noreen Akhtar (3609425)
Ishrat Jabeen (1284885)

December 2016

The data points in square and circle represent training and test set compounds respectively.</p

Diagrammatic representation of PI3K/AKT/mTOR signalling pathway detailing tested drug targets and overall ranking table.

Temitope Sasore (619737)
Breandán Kennedy (619738)

August 2014

Upon activation by receptor tyrosine kinase, PI3K lipid kinases are recruited to the plasma membr...

Distribution of tested inhibitors across the kinome.

Matthew Ryals (516790)
Kwang Pak (405682)
Rahul Jalota (4524190)
Arwa Kurabi (344167)
Allen F. Ryan (405683)

October 2017

The inhibitor targets are indicated in red. The kinome diagram is adapted, with permission, from ...

Schematic diagram of avibactam inhibition and deacylation pathways of KPC-2.

Nikhil P. Krishnan (792291)
Nhu Q. Nguyen (792292)
Krisztina M. Papp-Wallace (792293)
Robert A. Bonomo (188763)
Focco van den Akker (158508)

September 2015

Schematic diagram of avibactam inhibition and deacylation pathways of KPC-2.</p

Schematic diagram showing the chemical structure and pharmacological effects of DMH1 and compound C on Akt and glucose metabolism.

Xin Xie (311744)
Xiao-Ming Xu (188852)
Na Li (6550)
Yong-Hui Zhang (573497)
Yu Zhao (104852)
Chun-Yan Ma (632913)
De-Li Dong (5660674)

September 2014

DMH1 activated Akt and increased glucose metabolism; but compound C inhibited DMH1 –induced Akt a...

Number distribution of therapeutic peptides.

Wenhui Yan (825510)
Wending Tang (9241764)
Lihua Wang (14548)
Yannan Bin (6286199)
Junfeng Xia (192875)

September 2022

The upset plot shows the detailed number of therapeutic peptides in each group. In the upset plot, t...

Distribution of compound activity.

Jessica E. Hutti (146243)
Melissa A. Porter (146246)
Adam W. Cheely (146252)
Lewis C. Cantley (105082)
Xiaodong Wang (66801)
Dmitri Kireev (146259)
Albert S. Baldwin (146265)
William P. Janzen (146268)

July 2012

A–B) The kinase library was screened at 10 µM in a single concentration format against enzymatic ...

Pharmacophore Modeling, Virtual Screening, and Mo- lecular Docking Studies for Discovery of Novel Akt2 Inhibitors

Jia Fei
Lu Zhou
Tao Liu
Xiang-yang Tang

November 2015

licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that th...

The schematic diagram of tissue distribution of Compound 1 in Wistar rats after 180/kg of orally administered Compound 1 (mean ± S.D., n = 6).

Juan Wang (115708)
Xiaofeng Qu (577153)
Yanfei Qi (577154)
Jinhua Li (160513)
Xiuling Song (577155)
Li Li (14993)
Dehui Yin (577156)
Kun Xu (116877)
Juan Li (146180)

June 2014

The schematic diagram of tissue distribution of Compound 1 in Wistar rats after 180/kg of orally ...

Diagram showing the depressant action of H2 receptor antagonists.

Shuang Zhang (117657)
Zhiwei Xu (294494)
Yan Gao (93649)
Yonghong Wu (294495)
Zhihui Li (294496)
Haifeng Liu (117312)
Chenggang Zhang (294498)

February 2013

Diagram showing the depressant action of H2 receptor antagonists.</p

Schematic illustration of different inhibition mechanisms and the associated DSF signatures: A) GSH-competitive inhibition; B) conjugate-formation; C) ligandin-type.

Wendy A. Lea (167535)
Anton Simeonov (85099)

April 2012

Schematic illustration of different inhibition mechanisms and the associated DSF signatures: A) G...

Protein kinase inhibitors

Xerxa, Elena
Miljković, Filip
Bajorath, Jürgen

May 2023

The deposition contains data sets of human and mouse protein kinase inhibitors with reliable activit...

Pharmacological distribution diagram for Akt inhibitors obtained using the DF<sub>2</sub> (the <i>black colour</i> represents Akt inhibitors and the <i>white colour</i>, the compounds without Akt inhibition activity).

Abstract

Extracted data

Pharmacological distribution diagram for Akt inhibitors obtained using the DF<sub>2</sub> (the <i>black colour</i> represents Akt inhibitors and the <i>white colour</i>, the compounds without Akt inhibition activity).

Abstract

Extracted data

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