The MTOR/EIF4EBP1/YY1/MYC/SLC2A1 signaling mediated the chemopreventive effect of combined resveratrol and silymarin product on tumor growth: Total tumor size (A) and gross view of representative HCCs (B) with or without treatment of resveratrol (Res) and silymarin (Sily).

<p>Arrows indicate tumors. (C and D) Western blot analysis revealed a lower expression level of MTOR signal cascade in the treated cells and mice group (six smallest tumor adjacent tissues) than the untreated cells and mice group (six biggest tumor adjacent tissues). Quantitative results by coexpression of pre-S2 mutant and X proteins were relative to the untreated control cells and mice.